The fire of 1922 as quoted by the Worcester Democrat on April 22, 1922, as "The most disastrous conflagration in Pocomoke's History." The April 17 fire originated in an alley in the rear of the store owned by N. Davis and Sons and adjoining the stables of Frances M. Wilson on Maple Street. It swept away the main business section of town, many residences on Second, Willow, and Market Streets, and the entire residential section of Front and Bridge Streets. Not one home on the latter named thoroughfare remained standing when the holocaust had spent itself.